General Information

  • ID:  hor001356
  • Uniprot ID:  A0A8J5MJP5
  • Protein name:  FMRFamide-like peptide
  • Gene name:  NA
  • Organism:  Homarus americanus (American lobster)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Homarus (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SKNFLRF
  • Length:  7
  • Propeptide:  MIVAAWVLLTTLTWCCQAHAAPVPPVVAALDPPTDALLPAQSQEDDLFALPEKRLLKYFLPASQAWGGDAYPIGQEGTKRGYSDRNYLRFGRSDTNDYEGEEMPESPEKRNRNFLRFGRDQNRNFLRFGRSGSPMEFATDLQEDVELPVEEKRGAHKNYLRFGRGNRNFLRFGRGDRNFLRFGRSVDRQLSSLSCEDCDEEQKAREFTSTPSPTTIQPLARTKRDVSAVLSDDSIESSVLRQINAHRIKRAAAQNFYIPMAWASELQPEEDGIDVTSFEEPQVAKRFSHDRNFLRFGKRDGSDDYPSSSSSAESPAPVVVVRPVEYPRYVRAPSKNFLRFG
  • Signal peptide:  MIVAAWVLLTTLTWCCQAHA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001356_AF2.pdbhor001356_ESM.pdb

Physical Information

Mass: 101826 Formula: C43H66N12O10
Absent amino acids: ACDEGHIMPQTVWY Common amino acids: F
pI: 11.65 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -47.14 Boman Index: -1963
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 55.71
Instability Index: 1461.43 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20025296
  • Title:  Mass Spectral Analysis of Neuropeptide Expression and Distribution in the Nervous System of the Lobster Homarus Americanus